A crazy video from YouTube featuring our favorite stoner Dakota of Earth. This time around, he is high on "bufo". Can you really meet God by inbibing a secretion from a toad?! ChatGPT has some opinions...
What is "bufo"? I´m refering to some kind of psychedelic drug. Is it a form of DMT?
Yes, "Bufo" typically refers to the psychedelic secretion of the Bufo alvarius toad, also known as the Sonoran Desert toad or Colorado River toad. The psychoactive compound in this secretion is primarily 5-MeO-DMT, which is a powerful, fast-acting psychedelic.
🐸 What Is 5-MeO-DMT?
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5-MeO-DMT stands for 5-methoxy-N,N-dimethyltryptamine.
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It is a tryptamine, like regular DMT (N,N-DMT) found in ayahuasca and certain plants.
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However, 5-MeO-DMT is chemically distinct and has very different subjective effects.
🌬️ Effects of Bufo / 5-MeO-DMT
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Extremely rapid onset (within seconds of inhalation)
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Very short duration (usually 15–30 minutes)
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Intense dissolution of ego/self, sometimes described as “merging with the void,” “unified field,” or “pure consciousness”
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Less visionary than N,N-DMT — people often report light, energy, or white-out experiences rather than geometric patterns or entities
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Commonly described as more powerful and “ineffable” than other psychedelics
🔬 Differences: Bufo vs. DMT (Ayahuasca or Synthetic)
| Feature | Bufo (5-MeO-DMT) | DMT (N,N-DMT) |
|---|---|---|
| Source | Bufo alvarius toad secretion | Plants (e.g. chacruna), synthetic |
| Common form | Smoked or vaporized secretion | Smoked, snuffed, or orally as ayahuasca |
| Duration | 15–30 minutes | 30–60 minutes (smoked); 4–6 hrs (ayahuasca) |
| Visuals | Minimal to none | Often vivid, complex visuals and "entities" |
| Common themes | Ego death, nonduality, merging with Source | Spirit journeys, alien contact, otherworlds |
| Legality | 5-MeO-DMT is illegal in some countries (e.g. U.S.) | N,N-DMT is also scheduled in most places |
🌍 Ethical and Environmental Concerns
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Toad harvesting is controversial. Wild Bufo alvarius populations are under pressure due to demand.
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Synthetic 5-MeO-DMT is available and chemically identical, often seen as the more sustainable choice.
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Some Indigenous groups and psychedelic communities discourage using wild toads.
⚠️ Safety and Cautions
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Extremely potent; not recommended for beginners or unsupervised use
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Can cause overwhelming ego death, which some users find traumatic
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Should only be used with proper integration, preparation, and ideally a trained facilitator or guide
Would you like sources, maps of where the toads live, or details on how 5-MeO-DMT affects the brain?
5-MeO-DMT, the active compound in “Bufo,” profoundly affects the brain by binding to specific serotonin receptors, particularly 5-HT2A and 5-HT1A — which are involved in mood, perception, and consciousness.
🧠 How 5-MeO-DMT Affects the Brain
🔹 1. Serotonin Receptor Binding
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Primary action: strong agonism (activation) of the 5-HT2A receptor
This is the same receptor activated by LSD, psilocybin, and N,N-DMT — it's the “psychedelic receptor.” -
Also binds to:
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5-HT1A — linked to mood and anxiety regulation
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Possibly sigma-1 receptors, involved in consciousness, but this is less well understood
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🔹 2. Ego Dissolution and Default Mode Network (DMN) Suppression
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The Default Mode Network is a brain network associated with:
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Self-referential thinking
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The sense of identity (“ego”)
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Rumination and mental time travel (thinking about past and future)
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5-MeO-DMT heavily disrupts or quiets the DMN, which correlates with:
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Ego dissolution
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Loss of self–other boundaries
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Feelings of merging with a greater whole or consciousness
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Many users report this as a total loss of subject-object duality — often described as “nondual awareness” or “the void.”
🔹 3. Rapid Onset & Short Duration
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After inhalation, the compound crosses the blood–brain barrier very rapidly
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Peak effects occur within 1–2 minutes, and the experience resolves in ~20 minutes
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Because it's so fast, the brain doesn’t have much time to “process” or contextualize the experience, which may contribute to the ineffability of the state
🧬 Functional Brain Imaging (Early Findings)
There’s limited fMRI or EEG data on 5-MeO-DMT (compared to psilocybin or LSD), but preliminary studies and analogies suggest:
| Brain Effect | Likely Result in Experience |
|---|---|
| ↓ DMN coherence | Ego loss, unity consciousness |
| ↑ Connectivity across regions | “Hyper-consciousness,” sense of oneness |
| ↓ Activity in visual cortex | Lack of typical geometric hallucinations (unlike DMT) |
| ↑ Activity in limbic system | Deep emotional release, catharsis |
🧠 Comparison to Psilocybin and LSD
| Feature | 5-MeO-DMT | Psilocybin / LSD |
|---|---|---|
| Ego dissolution | Very common, extreme | Common, but often gradual |
| Visual hallucinations | Minimal | Prominent (esp. in LSD and DMT) |
| Emotional release | Often intense | Varies |
| Duration | 15–30 minutes | 4–8 hours |
| Subjective clarity | Ineffable, white-out | Often involves visions, stories, metaphors |
⚠️ Psychological & Spiritual Considerations
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Users often describe the experience as a "death and rebirth" or “merging with the absolute”
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Can lead to profound healing, spiritual awakening, or trauma, depending on set, setting, and integration
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Not recommended for people with certain mental health conditions (e.g. psychosis risk)
Would you like to see a brain activity diagram or studies comparing it directly to psilocybin or N,N-DMT?
The effects of N,N-DMT and 5-MeO-DMT differ dramatically because of chemical structure differences, receptor selectivity, and how they affect brain networks and perception. Here's a breakdown of why they produce such distinct experiences:
🔬 1. Chemical Structure Differences
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Both are tryptamines (related to serotonin), but:
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N,N-DMT: has a “linear” structure allowing for more interaction with sensory and visual pathways
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5-MeO-DMT: has a methoxy group at position 5, making it more potent at certain serotonin receptors and less visual in its effects
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⚖️ Result:
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N,N-DMT: more “structured,” visual, and entity-rich
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5-MeO-DMT: more “amorphous,” ego-dissolving, white-light/unity state
🧠 2. Different Receptor Affinities
| Receptor Type | N,N-DMT | 5-MeO-DMT |
|---|---|---|
| 5-HT2A (psychedelic) | Strong agonist | Even stronger agonist |
| 5-HT1A (mood/calm) | Mild | Very strong |
| Sigma-1 | Active | Possibly less active |
| Visual cortex targets | Stimulates | Less stimulation |
⚖️ Result:
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N,N-DMT produces:
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Vivid closed-eye visuals
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“Entity encounters” or “machine elf” phenomena
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Geometric, colorful, story-like journeys
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5-MeO-DMT produces:
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No or minimal visuals
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Overwhelming ego dissolution
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White light, merging with void or God
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🧠 3. Different Effects on Brain Networks
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N,N-DMT:
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Activates visual processing centers intensely
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Enhances cross-talk between brain regions, allowing for complex, symbolic, and narrative experiences
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5-MeO-DMT:
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Strongly suppresses Default Mode Network (DMN)
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Creates complete ego disintegration
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Less sensory input processing — more about nonduality, stillness, unity
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🎨 4. Subjective Effects: A Comparison
| Feature | N,N-DMT | 5-MeO-DMT (Bufo) |
|---|---|---|
| Visuals | Complex, colorful, fractal | Minimal or none |
| Entities | Common (elves, aliens, teachers) | Rare |
| Ego dissolution | Possible, but user often retains “observer” | Total, often overwhelming |
| Emotional tone | Varies (awe, terror, joy) | Often blissful, sometimes terrifying |
| Integration difficulty | High | Very high |
| Duration | ~15–45 minutes (smoked) | 15–30 minutes (vaporized) |
| Language use afterward | Users describe stories, visions | Users say it was “ineffable,” beyond language |
🌌 Summary Metaphor
Imagine N,N-DMT as being catapulted into an alien theme park full of vivid imagery and beings, where something seems to be “happening.”
Now imagine 5-MeO-DMT as being dissolved into pure white light, where there’s no self, no scene, no entities — just infinite presence or nothingness.
Would you like a chart summarizing this visually or sources from recent neuroscience research comparing both substances?
Datura is a highly toxic and powerful psychoactive plant used historically in ritual, shamanic, and religious contexts — including some related to Shaivism (the worship of Shiva) in India.
🌿 What is Datura?
Datura is a genus of plants in the nightshade family (Solanaceae), including species like:
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Datura stramonium (Jimsonweed)
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Datura inoxia
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Datura metel
🔬 Active compounds:
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Scopolamine
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Hyoscyamine
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Atropine
These are tropane alkaloids, which:
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Are anticholinergic (block acetylcholine in the nervous system)
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Can cause delirium, hallucinations, disorientation, amnesia, and strong physical effects (e.g. dry mouth, dilated pupils, elevated heart rate)
⚠️ Datura is extremely dangerous. Even small doses can lead to fatal poisoning or long-term psychosis.
🕉️ Datura in Hinduism and the Shiva Cult
Yes, Datura has a connection to Shiva worship, particularly in Tantric and folk Shaivite traditions. Here's how:
🔹 1. Offerings to Shiva
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Datura flowers and seeds are traditionally offered to Shiva, especially during festivals like Mahashivaratri.
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The plant is associated with Shiva’s ascetic, destructive, and wild aspects.
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It’s one of the few toxic plants considered sacred in this context.
According to legend, Shiva consumed poison during the churning of the ocean (Samudra Manthan), which is symbolically linked to the offering of toxic plants like Datura.
🔹 2. Tantric and Aghori Use
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In Tantric Shaivism, particularly in Aghori and Nath sects, Datura may be used in ritual intoxication to:
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Break conventional mental boundaries
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Enter altered states
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Confront death and ego
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Aghoris, who worship Shiva in his form as Bhairava, may use Datura in extreme rituals, though this is rare and highly esoteric.
🧠 Effects in Ritual Context
Unlike classic psychedelics like psilocybin or ayahuasca, Datura produces delirium, not insight or ego dissolution. Effects include:
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Hallucinations indistinguishable from reality
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Talking to people who aren't there
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Complete amnesia afterward
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A sense of death, decay, or spiritual trial
This made it useful in initiation rites or “death-and-rebirth” experiences in some traditions — but it is extremely unpredictable and dangerous.
📜 Summary
| Aspect | Detail |
|---|---|
| Plant type | Psychoactive nightshade (toxic, deliriant) |
| Main compounds | Scopolamine, atropine, hyoscyamine |
| Hindu connection | Sacred to Shiva; used as offering |
| Ritual use | Rare use in Tantric and Aghori sects |
| Experience | Delirium, hallucinations, amnesia, spiritual crisis |
| Risk | High – can be fatal or cause psychosis |
Would you like more detail on Aghori rituals or the symbolism of Shiva in relation to poisonous plants?
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